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” He and Munakata think that gradual modifications in just how the DNA is saved could lead to the lack of fertility as Females age. If that is so, their exploration could pave the way for enhanced treatment method and prognosis of fertility complications.
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Get the job done by Namekawa and Munakata indicates that a crucial function comes about round the time of birth: the nascent egg cells enter a holding pattern, with their DNA exactly packaged and primed for fertilization later on in life.
Munakata and Namekawa will Examine mice with typical and mutated variations of your chromatin remodeler. As the mice grow and experienced, they're going to notice whether the existence or absence of the protein triggers variations while in the arrangement of DNA spools from the animals’ oocytes. And they're going to observe no matter if this, subsequently, alters the pattern of gene expression with time.
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